A Molecular, Genetic, and Diagnostic Spotlight on Fanconi Anemia
نویسندگان
چکیده
منابع مشابه
A Molecular, Genetic, and Diagnostic Spotlight on Fanconi Anemia
1Division of Hematology & Oncology, School of Medicine, Oregon Health & Science University, 3710 SW US Veterans Hospital Road, R&D-2, Portland, OR 97239, USA 2Stem Cell and Leukaemia Proteomics Laboratory and Paediatric and Adolescent Oncology, University of Manchester, Royal Manchester Children’s Hospital and The Christie NHS Foundation Trust, Manchester Academic Health Science Centre, Manches...
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BACKGROUND AND OBJECTIVE Fanconi anemia (FA) is an autosomal recessive disease characterized by pancytopenia, congenital malformation and high predisposition to developing malignancies. The phenotypical heterogeneity is associated with genetic heterogeneity: at least 8 complementation groups (FA-A to FA-H) have been identified, each group presumably corresponding to a separate disease gene (FAA...
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A rare genetic disease, Fanconi anemia (FA), now attracts broader attention from cancer biologists and basic researchers in the DNA repair and ubiquitin biology fields as well as from hematologists. FA is a chromosome instability syndrome characterized by childhood-onset aplastic anemia, cancer or leukemia susceptibility, and cellular hypersensitivity to DNA crosslinking agents. Identification ...
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In recent years, Fanconi anemia (FA) has been the subject of intense investigations, primarily in the DNA repair research field. Many discoveries have led to the notion of a canonical pathway, termed the FA pathway, where all FA proteins function sequentially in different protein complexes to repair DNA cross-link damages. Although a detailed architecture of this DNA cross-link repair pathway i...
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Author’s Affi liation: Departments of Radiation Oncology and Pediatrics, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts Corresponding Author: Alan D. D’Andrea, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215. Phone: 617-632-2112; Fax: 617-632-5757; E-mail: [email protected] doi: 10.1158/2159-8290.CD-13-0044 ©2013 American Association...
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ژورنال
عنوان ژورنال: Anemia
سال: 2012
ISSN: 2090-1267,2090-1275
DOI: 10.1155/2012/650730